Age-Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All-Cause Mortality in a Sardinian Population Cohort.

Richard Oppong, Valeria Orru, Michele Marongiu, Yong Qian, Carlo Sidore, Alessandro Delitala, Marco Orru, Antonella Mulas, Maria Grazia Piras, Christopher H Morrell, Sandra Lai, David Schlessinger, Myriam Gorospe, Francesco Cucca, Edoardo Fiorillo, Jun Ding, Edward G Lakatta, Angelo Scuteri

National Institute on Aging - Intramural Research Program NIH Baltimore MD. · pubmed

Paper

Abstract

Growth differentiation factor 15 (GDF-15) levels are emerging as a candidate biomarker of aging. The present study aimed to: (1) characterize the association of GDF-15 with the continuum of arterial stiffening, assessed as carotid-femoral pulse wave velocity, as age increases; (2) determine the predictive role of serum GDF-15 levels on mortality; and (3) identify genetic determinants of serum GDF-15 levels.

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Research summary

The study claims that higher levels of GDF-15 correlate with increased arterial stiffness and predict all-cause mortality. This paper is relevant as it investigates a potential biomarker (GDF-15) associated with aging and its implications for mortality, contributing to the understanding of aging mechanisms.

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