Rejuvenation to the Heart: Overcoming Age-Related Metabolic Barriers in Direct Cardiac Reprogramming.

Pedro P Cunha, Mariana Lopes

Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. · pubmed

Abstract

By dissecting metabolic and epigenetic features imposed by ageing in cardiomyocyte conversion from fetal and adult mouse fibroblasts, Santos et al. describe that metabolic modulation can enhance direct cardiac reprogramming.

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Research summary

Metabolic modulation can enhance direct cardiac reprogramming in the context of age-related metabolic barriers. This research addresses the underlying metabolic and epigenetic factors associated with aging, which are crucial for advancing our understanding of rejuvenation strategies in cardiac tissue.

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