Intestinal microbiota profiles of captive-bred cynomolgus macaques reveal influence of biogeography and age.

C Purse, A Parker, S A James, D J Baker, C J Moss, R Evans, J Durham, S G P Funnell, S R Carding

Food, Microbiome and Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK.Food, Microbiome and Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, NR4 7UQ, UK. · pubmed

Paper

Abstract

Age-associated changes to the intestinal microbiome may be linked to inflammageing and the development of age-related chronic diseases. Cynomolgus macaques, a common animal model in biomedical research, have strong genetic physiological similarities to humans and may serve as beneficial models for the effect of age on the human microbiome. However, age-associated changes to their intestinal microbiome have previously only been investigated in faecal samples. Here, we have characterised and investigated the effects of age in the cynomolgus macaque intestinal tract in luminal samples from both the small and large intestine.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that age-associated changes in the intestinal microbiome of cynomolgus macaques can provide insights into the effects of aging on the human microbiome. This research is relevant as it explores the relationship between microbiome changes and aging, which could contribute to understanding the root causes of age-related diseases.

Author of this paper? Send a correction.