How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies.

Lin Hu, Jiayuan Li, Zihuan Tang, Peng Gong, Zongqi Chang, Chen Yang, Tianpei Ma, Shuang Jiang, Chunxia Yang, Tao Zhang

Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. · pubmed

Paper

Abstract

Recent basic biological research found that obesity accelerates biological aging and increases cardiovascular disease (CVD) risk. However, there is still a lack of real-world population evidence. This study aimed to explore the potential mediation roles of biological age acceleration in the associations between different dimensions of obesity characterization and incident CVD.

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Research summary

The paper claims that biological age acceleration mediates the relationship between obesity and cardiovascular disease risk. This research is relevant as it explores the underlying mechanisms linking obesity to biological aging and cardiovascular health, which are critical factors in longevity and age-related diseases.

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