BDNF alleviates senescence and enhances osteogenic differentiation in bone marrow mesenchymal stem cells via the TrkB/PI3K/AKT pathway.

Jimei Zhang, Ling Zhu, Jianping Zhou, Qunying Yu, Guangyuan Yang, Chaoli Luo, Jianguo Meng, Shan Xing, Jing Liu, Donggang Mou, Xuming Yang

Gastroenterology Department, Chenggong Hospital, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650505, China. · pubmed

Paper

Abstract

Bone marrow mesenchymal stem cells (BMSCs) are stem cells that reside in bone marrow and have multidirectional differentiation potential. BMSCs have been used to treat bone injury. However, long-term passage leads to the aging of BMSCs and the weakening of osteogenic differentiation. Furthermore, brain-derived neurotrophic factor (BDNF) may enhance the antiaging ability of BMSCs. The purpose of this study was to investigate the role of BDNF in the senescence and osteogenic differentiation of human BMSCs (hBMSCs).

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Research summary

BDNF enhances the antiaging ability of bone marrow mesenchymal stem cells by alleviating senescence and promoting osteogenic differentiation through the TrkB/PI3K/AKT pathway. The study addresses the aging of stem cells, which is a fundamental aspect of longevity research, focusing on mechanisms that could potentially mitigate age-related decline in stem cell function.

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