CaMK modulates sensory neural activity to control longevity and proteostasis.

Ranran Zhao, Weiqi Ge, Weikang Xue, Zaidong Deng, Jiaze Liu, Kaiqi Wang, Youngnam N Jin, Yanxun V Yu

Department of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.Department of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China. · pubmed

Paper

Abstract

The impact of neural activity on aging and longevity remains poorly understood, with limited understanding of the specific neuron groups and molecular mechanisms that regulate lifespan. In this study, we uncover a correlation between human longevity and reduced CaMK4 expression in the frontal cortex. We further show that this link is conserved in

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study claims that reduced CaMK4 expression in the frontal cortex correlates with human longevity. This research is relevant as it investigates the molecular mechanisms that may influence lifespan, addressing the root causes of aging rather than merely treating age-related symptoms.

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