Sex-specific associations between per- and polyfluoroalkyl substance exposure and epigenetic age: Findings from the National Health and Nutrition Examination survey 1999-2000.

Dennis Khodasevich, Anne K Bozack, Belinda L Needham, David H Rehkopf, Andres Cardenas

Department of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA. Electronic address: [email protected] of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

Per-and polyfluoroalkyl substances (PFAS) are a pervasive family of synthetic compounds with a wide range of reported health effects. Epigenetic clocks, DNA methylation-based predictors of chronological and biological age, are promising biomarkers for characterizing biological aging in humans. The potential impact of PFAS exposure on epigenetic aging in the general US population remains unclear. In the 1999-2000 National Health and Nutrition Examination Survey (NHANES) cycle (N = 262), eleven PFASs were measured in serum and DNA methylation was measured in blood with the EPICv1 array. Seven epigenetic clocks and their respective epigenetic age acceleration (EAA) measures were calculated. Survey-design weighted generalized linear regression models were used to test adjusted associations between individual log

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Research summary

The paper investigates the associations between PFAS exposure and epigenetic age acceleration. This research is relevant as it explores environmental factors that may influence biological aging, contributing to our understanding of aging mechanisms.

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