Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice.

Shixiong Zhang, Xinjing Mao, Liping Chang, Mengnan Li, Cong Wei, Hongrong Li, Xiaogang Shen, Kunxu Niu, Runtao Zhang, Yuning Jiang, Xuan Lu, Yahui Song, Liangxing Zhou, Lini Gao, Zhiqin Zhao, Liying Niu, Qian Yang, Yunlong Hou, Yiling Wu

Hebei Provincial Hospital of Chinese Medicine, Shijiazhuang, 050011, China; Nanjing University of Chinese Medicine, Nanjing, 210023, China; Hebei Key Laboratory of Turbidity Toxin Syndrome, Shijiazhuang, 050011, China; State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China. Electronic address: [email protected] Provincial Hospital of Chinese Medicine, Shijiazhuang, 050011, China; Nanjing University of Chinese Medicine, Nanjing, 210023, China; Hebei Key Laboratory of Turbidity Toxin Syndrome, Shijiazhuang, 050011, China; State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Bazi Bushen Capsule (BZBS), a traditional Chinese medicine formulation composed of multiple bioactive herbal components, has been validated in multicenter randomized double-blind controlled trials for its potent anti-aging properties. Previous studies from our group have demonstrated that BZBS effectively restores gut microbiota homeostasis and attenuates the impairment of intestinal barrier function, thereby ameliorating age-related cognitive decline. However, the specific molecular mechanisms by which BZBS modulates key microbial-metabolite networks to delay brain aging remain poorly understood and warrant further investigation.

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Research summary

Bazi Bushen Capsule modulates gut microbiota and spermidine metabolism to mitigate brain aging. The study addresses mechanisms that may contribute to aging processes, focusing on gut health and cognitive decline, which are relevant to longevity research.

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