Exosomes derived from human umbilical cord mesenchymal stem cells attenuate senescence of peritoneal mesothelial cells by inhibiting oxidative stress.

Jia Li, Lixin Liu, Yiman Chen, Yuling Huang, Lina Yang

Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China. · pubmed

Paper

Abstract

Aging is a natural process that affects cellular function. In peritoneal dialysis (PD), chronic exposure to dialysate induces oxidative stress (OS) in peritoneal mesothelial cells (PMCs), leading to cellular aging, fibrosis, and reduced dialysis efficacy. Mesenchymal stem cells (MSCs) have shown potential in alleviating cellular aging. This study investigates the role of exosomes (hUMSC-Exos) derived from human umbilical cord MSCs (hUMSCs) in mitigating PMC senescence and explores the underlying mechanisms.

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Research summary

Exosomes derived from human umbilical cord mesenchymal stem cells can mitigate senescence in peritoneal mesothelial cells by reducing oxidative stress. This research addresses a mechanism related to cellular aging, which is pertinent to longevity studies.

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