Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.

Qi Zhang, Shujie Cao, Min Zhang, Daming Wu, Chengfei Zhang, Jin Li

Department of Geriatric Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China. · pubmed

Paper

Abstract

This study aimed to evaluate the effects of Biodentine on human Dental Pulp Stem Cells (hDPSCs) proliferation and senescence and explore the underlying anti-aging mechanism.

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Research summary

Biodentine enhances the proliferation of human Dental Pulp Stem Cells and counteracts their senescence via the Wnt/β-Catenin pathway. This research addresses cellular aging mechanisms, which is pertinent to longevity studies.

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