Lower Diastolic Velocity in the Internal Carotid Artery Mediates Lower Cerebral Blood Flow With Age.
Abstract
Advanced aging is characterized by reduced cerebral blood flow (CBF) and increased central arterial stiffness. Increased arterial stiffness is associated with increased CBF pulsatility, which is detrimental to cerebrovascular integrity. We examined the associations between central arterial stiffness, diastolic, systolic, and total CBF in healthy cognitively normal subjects (n=163, age 20-81 years, 62% female) who underwent color-coded duplex ultrasonography of the internal carotid (ICA) and the vertebral artery (VA) to measure pulsatile CBF and total CBF. Cerebral tissue oxygenation was measured using near-infrared spectroscopy (NIRS). Carotid β-stiffness index and carotid-femoral pulse wave velocity (cfPWV) were assessed via applanation tonometry and ultrasonography to assess central artery stiffness. Age was negatively associated with total CBF (R
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Research summary
The paper claims that lower diastolic velocity in the internal carotid artery mediates lower cerebral blood flow with age. This research is relevant as it explores the relationship between arterial stiffness and cerebral blood flow, which are critical factors in understanding the physiological changes associated with aging and their potential impact on longevity.
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