Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights.

Meijie Jiang, Yuting Wang, Sifan Tian, Shuzhen Liu, Yaxin Luo, Haocan Song, Jian Qin, Yuebin Lv, Andrea A Baccarelli, Zhiyong Zhang, Xiaoming Shi, Xu Gao

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100191, China. · pubmed

Paper

Abstract

Frailty is an underappreciated but modifiable clinical syndrome, but little about how air quality improvements could influence frailty progression is known. Here, we utilized two Chinese cohorts with repeated follow-up visits to address this knowledge gap and explored the underlying DNA methylation mechanisms. We first conducted a multistate modeling analysis in the Chinese Longitudinal Healthy Longevity Study (CLHLS), a nationwide cohort with 21,654 older adults who had participated in at least two survey waves. An interquartile range reduction in PM

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Research summary

Air pollution control can slow the progression of frailty in older adults through underlying DNA methylation mechanisms. This paper addresses a modifiable factor related to aging and frailty, which are critical aspects of longevity research.

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