Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells.

Wenbo Wu, Mengying Bai, Wenli Hong, Shuyi Ling, Yuan Li, Yuqing Dai, Ruoxin Weng, Haifeng Wu, Chongyang Ren, Liujuan Zhang, Ziqiong Zhou, Zhisheng Zhong, Xinxin Fu, Yuehui Zheng

The Fourth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, Guangdong, China.The Fourth Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, Guangdong, China. · pubmed

Paper

Abstract

As women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delaying ovarian aging by replenishing the primordial follicle pool. Therefore, activating FGSCs is critical in reshaping and safeguarding ovarian function.

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Research summary

Proanthocyanidins can delay premature ovarian insufficiency by activating the sirt1-p53-p21 signaling pathway in female germline stem cells. This research addresses the aging process in ovarian function, which is directly related to longevity and the preservation of reproductive health in aging women.

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