Adropin contributes to the nephro-protective effect of vitamin D in renal aging in a rat model via MAPK/HIFα/VEGF/eNOS mechanism.

Heba S Youssef, Walaa H Mohammed, Walaa Bayoumie El Gazzar, Amina A Farag, Esraa H Khairat, Neama E Abdelmaksoud, Manar A Elkholy, Amira Elalfy, Tayseer A Ibrahim

Faculty of Medicine, Department of Physiology, Benha University, Egypt.Faculty of Medicine, Department of Physiology, Benha University, Egypt. · pubmed

Paper

Abstract

Great efforts have been established to promote healthy aging and prevent illnesses connected to aging. The prevalence of elderly population increases and this will be associated with an increase in disability and illness. This study analyzed renal aging process following administration of D-galactose (120 mg/kg/d ip for 8 weeks), and the potential protective effects of vitamin D administration (1,000 and 10,000 IU/kg/d by oral gavage for 8 weeks) in animals with D-galactose induced aging. The renal function tests (serum urea and creatinine, creatinine clearance, and 24 hours urinary albumin excretion levels), oxidative stress (MDA, TCA), renal tissue expression of TNFα, HIFα, Adropin, MAPK, eNOS, and VEGF as well as histopathological and EM alterations were assessed. D-galactose administration resulted in noticeable changes in renal histopathology, deteriorated renal function tests, elevated oxidative stress and inflammation, and significantly diminished Adropin, MAPK, eNOS, HIFα and VEGF expression. Vitamin D effectively reversed these alterations and enhanced histopathological and EM ultrastructure changes triggered by D-galactose administration.

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Research summary

The paper claims that vitamin D administration can reverse renal aging processes in a rat model through the modulation of specific molecular pathways. This research is relevant as it explores potential interventions that target mechanisms of aging, specifically in the context of renal function and oxidative stress, which are critical aspects of healthy aging.

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