Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons.

Nimmy Varghese, Leonora Szabo, M Zameel Cader, Imane Lejri, Amandine Grimm, Anne Eckert

Research Cluster Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.Research Cluster Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland. · pubmed

Paper

Abstract

This study aims to determine if neurons derived from induced pluripotent stem cells (iPSCsNs) and directly converted neurons (iNs) from the same source cells exhibit changes in mitochondrial properties related to aging. This research addresses the uncertainty around whether aged iPSCsNs retain aging-associated mitochondrial impairments upon transitioning through pluripotency while direct conversion maintains these impairments. We observe that both aged models exhibit characteristics of aging, such as decreased ATP, mitochondrial membrane potential, respiration, NAD

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Research summary

The paper claims that both aged iPSCs-derived neurons and directly converted neurons exhibit aging-related mitochondrial impairments. This research is relevant as it investigates the underlying mitochondrial changes associated with neuronal aging, which could contribute to understanding the mechanisms of aging and potential interventions.

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