The association between secondhand smoke exposure and accelerated biological aging: A population-based study and Mendelian randomization analysis.

Yue Zhu, Yufan Gao, Yangguang Lu, Yukai Wang, Ziyu Pan, Huixiang Sheng, Jiajun Li, Yinuo Chen, Jialing Lou, Feng Chen, Fajing Yang

The School of Public Health and Management, Wenzhou Medical University, Wenzhou, China.The School of Public Health and Management, Wenzhou Medical University, Wenzhou, China. · pubmed

Paper

Abstract

Aging is an irreversible biological process significantly influenced by oxidative stress, which smoking exacerbates. While the impact of direct smoking on aging is well-documented, the association between secondhand smoke (SHS) exposure and biological aging remains less explored. This study examines the connection between SHS exposure in populations and biological aging, highlighting diabetes as a potential mediator due to its established links to both SHS exposure and accelerated aging through mechanisms such as oxidative stress and chronic inflammation. It further employs genetic tools to establish a causal relationship between SHS exposure and biological aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that secondhand smoke exposure is causally linked to accelerated biological aging. This study is relevant as it explores the impact of environmental factors on biological aging, addressing a potential root cause of aging through the lens of oxidative stress and chronic inflammation.

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