NF-κB-mediated developmental delay extends lifespan in

Ping Kang, Peiduo Liu, Yanhui Hu, Jinoh Kim, Ankur Kumar, Marlene K Dorneich-Hayes, Wren Murzyn, Zenessa J Anderson, Lexi N Frank, Nicholas Kavlock, Elizabeth Hoffman, Chad C Martin, Ting Miao, MaryJane Shimell, Jo Anne Powell-Coffman, Michael B O'Connor, Norbert Perrimon, Hua Bai

Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011.Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011. · pubmed

Paper

Abstract

Developmental time (or time to maturity) strongly correlates with an animal's maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phenomenon remain largely unknown. This may be because most previously identified longevity genes regulate growth rate rather than developmental time. To address this gap, we genetically manipulated prothoracicotropic hormone (PTTH), the primary regulator of developmental timing in

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Research summary

Manipulating prothoracicotropic hormone (PTTH) can extend lifespan by influencing developmental timing. This research addresses the genetic mechanisms underlying the correlation between developmental time and maximum lifespan, contributing to the understanding of longevity and potential lifespan extension strategies.

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