Association of Hypoxemia Due to Obstructive Sleep Apnea With White Matter Hyperintensities and Temporal Lobe Changes in Older Adults.

Destiny E Berisha, Batool Rizvi, Miranda G Chappel-Farley, Nicholas Tustison, Lisa Taylor, Abhishek Dave, Negin S Sattari, Ivy Y Chen, Kitty K Lui, John C Janecek, David B Keator, Ariel B Neikrug, Ruth M Benca, Michael A Yassa, Bryce A Mander

Department of Neurobiology and Behavior, University of California Irvine.Department of Neurobiology and Behavior, University of California Irvine. · pubmed

Paper

Abstract

Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline and functional loss in older adults. Obstructive sleep apnea (OSA) is common in older adults, can increase cerebrovascular disease risk, and is linked to medial temporal lobe (MTL) degeneration and cognitive impairment. However, the interaction between OSA features and CSVD burden and their combined effect on MTL structure and function are not well understood. This study tested the hypothesis that CSVD burden is a candidate mechanism linking OSA to MTL degeneration and impaired memory in older adults.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study hypothesizes that the burden of cerebral small vessel disease mediates the relationship between obstructive sleep apnea and medial temporal lobe degeneration in older adults. This paper is relevant as it explores the mechanisms linking a common age-related condition (OSA) to cognitive decline, which is a significant aspect of aging research.

Author of this paper? Send a correction.