Neuromodulation by repetitive paired-pulse TMS at late I-wave intervals in older adults.

Wei-Yeh Liao, Brodie J Hand, Giuseppe Rinaldi, John G Semmler, George M Opie

Discipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia. [email protected] of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia. [email protected]. · pubmed

Paper

Abstract

The efficacy of indirect (I) wave periodicity repetitive transcranial magnetic stimulation (iTMS) on the excitability of primary motor cortex (M1) in young adults can be modified by changing the late I-wave interval. Given that late I-wave activity is altered in older adults, this could contribute to age-related changes in M1 plasticity. To assess this possibility, the present study investigated the effects of iTMS using three late I-wave intervals (4.0, 4.5, and 5.0 ms) on M1 excitability in 17 older adults (69.6 ± 5.7 years; 10 females), which was compared to findings obtained previously in 17 young adults (27.2 ± 6.4 years, 12 females). Changes in M1 excitability were assessed using motor evoked potentials (MEPs) recorded from the right first dorsal interosseus to index single-pulse MEP

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Research summary

The study investigates the effects of iTMS on M1 excitability in older adults, suggesting that modulation of cortical excitability could address age-related changes in brain plasticity. This research is relevant as it explores potential interventions that may improve neural function in aging, contributing to our understanding of mechanisms that could mitigate age-related decline.

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