Sex-specific cardiac electrophysiological remodeling influences the susceptibility to arrhythmias in elderly rats.

Rosario Statello, Giovanna Pelà, Roberta Maestri, Fabio Leonardi, Aderville Cabassi, Ignazio Verzicco, Alessandra Rossi, Luca Carnevali, Paolo Pastori, Domenico Corradi, Michele Miragoli, Emilio Macchi, Stefano Rossi

Department of Medicine and Surgery, University of Parma, Parma, Italy. · pubmed

Paper

Abstract

Advanced age is a well-known risk factor for cardiovascular disease (CVD), with sex differences contributing significantly to age-dependent clinical heterogeneity. The incidence of CVD increases with age in both sexes, although men and women are predisposed toward different CVDs. However, the sex-specific arrhythmogenic alterations in aged individuals are still not described in depth. The present work aimed to analyze gross anatomical and relevant cardiac electrophysiological parameters

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Research summary

The paper claims that sex-specific cardiac electrophysiological remodeling influences susceptibility to arrhythmias in elderly rats. This research is relevant as it explores age-related cardiovascular changes and their implications, contributing to the understanding of sex differences in aging and potential interventions.

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