Loss of WDR23 slows the rate of age-related cognitive decline with elevated amyloid burden.

Jiahui Liu, Chatrawee Duangjan, Nguyen M Phan, Sean P Curran

University of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.University of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA. · pubmed

Paper

Abstract

BackgroundWDR23 is a regulator of cellular proteostasis and oxidative stress response processes that are critically involved in the pathogenesis of Alzheimer's disease (AD). Dysregulation of these pathways can contribute to amyloid-β (Aβ) and tau pathologies, ultimately leading to cognitive impairment.ObjectiveWe explored the effects of

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Research summary

Loss of WDR23 slows age-related cognitive decline despite elevated amyloid burden. The paper is relevant as it investigates a potential mechanism that could influence the underlying processes of aging and cognitive decline, rather than merely addressing symptoms.

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