Epimedii Folium and Curculiginis Rhizoma ameliorate age-related cognitive decline and neuroinflammation through modulation of the NLRP3 inflammasome.

Jiaqi Ji, Biqun Zhang, Junzuo Zheng, Xuesong Zhang, Xiaosong Hu, He Zhu, Ping Wang, Zhou Lan

School of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, PR China.School of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, PR China. · pubmed

Paper

Abstract

Age-related cognitive decline and neuroinflammation are significant contributors to neurodegenerative diseases. In Traditional Chinese Medicine, aging is often associated with "kidney deficiency," a concept linked to impaired bone marrow production and brain function. Epimedii Folium and Curculiginis Rhizoma (XY), a classic herbal pair used to tonify the kidney, are traditionally employed to enhance vitality, bone health, and cognitive function. While previous studies suggest XY's efficacy in pathological models, its impact on natural aging process requires further investigation.

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Research summary

Epimedii Folium and Curculiginis Rhizoma may improve cognitive function and reduce neuroinflammation associated with aging. The paper addresses age-related cognitive decline, which is a significant aspect of the aging process, and explores potential interventions that could influence the underlying mechanisms of aging rather than merely treating symptoms.

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