Transcriptomic and lipidomic analysis of aging-associated inflammatory signature in mouse liver.

Tomoaki Ishihara, Hiroshi Tsugawa, Seigo Iwanami, Jen-Chien Chang, Aki Minoda, Makoto Arita

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. [email protected] for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. [email protected]. · pubmed

Paper

Abstract

Aging-associated dysbiosis leads to chronic inflammation and the development of a range of aging-related diseases. The gut microbiota crosstalks with the host by providing lipid metabolites and modulating metabolic functions. However, the precise mechanism by which the gut microbiota regulates aging is unknown. The objective of this study was to examine the impact of the gut microbiota on the transcriptome and lipidome associated with aging in mouse liver.

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Research summary

The study investigates the role of gut microbiota in modulating the transcriptome and lipidome associated with aging in mouse liver. This research is relevant as it explores potential mechanisms underlying aging and chronic inflammation, which are central to understanding and potentially mitigating age-related diseases.

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