Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.

Xiao Liang, Jingyuan Zhang, Jiangbo Yu, Jiyi Zhao, Shusen Yang

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China. · pubmed

Paper

Abstract

Atherosclerosis (AS), a chronic inflammatory disease of the arterial wall, remains a dominant cause of death and disability globally. Quercetin has been evidenced to be effective against AS, but the exact mechanisms are still largely unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Quercetin mitigates cellular senescence in aortic endothelial cells and macrophages through specific signaling pathways. This research addresses mechanisms related to cellular senescence, which is a key factor in aging and age-related diseases, thus contributing to the understanding of longevity.

Author of this paper? Send a correction.