Metabolic profiling of the Chinese population with extreme longevity identifies Lysophospholipid species as potential biomarkers for the human lifespan.
Abstract
Metabolic regulation plays a crucial role in extending the healthspan and lifespan across multiple organisms, including humans. Although numerous studies have identified the characteristics of the metabolome and potential biomarkers in long-lived populations worldwide, the metabolome landscape of Chinese centenarians remains largely unknown. This study characterised the plasma metabolic profiles of Chinese centenarians and nonagenarians and identified potential biomarkers of longevity.
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Research summary
The study identifies specific lysophospholipid species as potential biomarkers associated with longevity in the Chinese population. This research is relevant as it explores metabolic factors that may contribute to extending lifespan and healthspan, addressing the biological underpinnings of aging rather than merely treating age-related diseases.
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