Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis.

Yanpeng Lin, Hangtian Wu, Jun Wang, Wanling He, Jiahui Hou, Vidmi Taolam Martin, Chencheng Zhu, Yupeng Chen, Junyuan Zhong, Bin Yu, Aiping Lu, Daogang Guan, Genggeng Qin, Weiguo Chen

Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China. · pubmed

Paper

Abstract

Chondrocyte senescence, synovitis, and decreased level of lubrication play pivotal roles in the pathogenesis of age-related osteoarthritis (AROA). However, there are currently no effective therapeutic interventions capable of altering the progression of OA until it reaches advanced stages, necessitating joint replacement. In this study, lubricious and drug-loaded hydrogel microspheres were designed and fabricated by utilizing microfluidic technology for radical polymerization of chondroitin sulfate methacrylate and incorporating nicotinamide adenine dinucleotide (NAD)-loaded liposomes modified with lactoferrin that are positively charged. Mechanical, tribological, and drug release analyses demonstrated enhanced lubrication properties and an extended drug dissemination time for the NAD@NPs@HM microspheres.

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Research summary

The paper claims that NAD-loaded hydrogel microspheres can alleviate age-related osteoarthritis through improved lubrication and drug delivery. This research addresses a significant aspect of aging-related joint degeneration, which is relevant to longevity by exploring potential therapeutic interventions that could alter the progression of age-related diseases.

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