miR‑34a induces apoptosis and pyroptosis in D‑Galactose‑induced aging cochlear hair cells via inhibiting TFAM and promoting mitochondrial dysfunction

Yilan Wang, Ming Yang, Guihua Wang, Weimin Liu, Bin Deng, Xiaoran Yang, Xuzhao Li

Department of Otolaryngology Head and Neck Surgery, People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, Ningxia Hui 750002, P.R. China.Department of Otolaryngology Head and Neck Surgery, People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, Ningxia Hui 750002, P.R. China. · pubmed

Paper

Abstract

Aging of the auditory system causes progressive hearing deficit and affects millions of people; however, the underlying mechanism remains largely unknown. D‑galactose (D‑gal)‑induced aging models were established

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Research summary

The paper claims that miR-34a induces apoptosis and pyroptosis in aging cochlear hair cells by inhibiting TFAM and promoting mitochondrial dysfunction. This research addresses mechanisms of cellular aging and potential pathways involved in age-related hearing loss, contributing to the understanding of aging processes.

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