Umbilical Cord Blood Plasma Enhances Cellular Repair and Senescence Suppression in Human Dermal Fibroblasts Under Oxidative Stress.

Miso Jeong, Hyangju Lee, Tae-Hyun Ko, Soo Jin Choi, Wonil Oh, Sangwoo Kim

Research Institute of Advanced Regenerative Medicine, MEDIPOST Co., Ltd., Seongnam, South Korea.Research Institute of Advanced Regenerative Medicine, MEDIPOST Co., Ltd., Seongnam, South Korea. · pubmed

Paper

Abstract

Aging is associated with a gradual decline in cellular function, largely driven by oxidative stress, which leads to cellular senescence. These processes contribute to tissue degeneration and age-related dysfunction. Human dermal fibroblasts (HDFs), critical for maintaining skin structure, are highly vulnerable to oxidative damage, making them key contributors to skin aging. Umbilical cord blood plasma (UCBP), rich in growth factors and regenerative molecules, has shown potential in preventing cellular senescence and addressing key mechanisms of tissue aging. Based on findings from heterochronic parabiosis experiments that demonstrated the rejuvenating effect of young blood, we investigated the effects of UCBP on hydrogen peroxide (H

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Research summary

Umbilical cord blood plasma enhances the repair of human dermal fibroblasts and suppresses cellular senescence under oxidative stress. This research addresses mechanisms of cellular aging and potential interventions to mitigate age-related decline, aligning with the goals of longevity research.

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