Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes.

Wei Liu, Yadan Xiao, Manting Zeng

Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. · pubmed

Paper

Abstract

Increasing age is a risk factor of gastroesophageal reflux disease. This study aims to uncover the shared genetic architecture of gastroesophageal reflux disease (GERD) and age-related phenotypes. Based on publicly available GWAS statistics, this genome-wide pleiotropic association research was performed with multiple genetic approaches sequentially to explore the pleiotropic associations from single-nucleotide polymorphism (SNP) and gene levels, to reveal the underlying shared genetic etiology between GERD and age-related phenotypes. This study featured shared genetic mechanisms between GERD and age-related phenotypes, including frailty index (FI), telomere length (TL), longevity, and parental lifespan (PL). Strong genetic association were observed. A set of pleiotropic loci and genes were identified by PLACO, FUMA, Bayesian colocalization and additional MAGMA analysis. Our research provided strong evidence of genetic correlation between GERD and several age-related phenotypes, especially frailty index (FI) and telomere length (TL), brought novel insight into the shared genetic architecture between GERD and aging.

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Research summary

The paper identifies shared genetic mechanisms between gastroesophageal reflux disease and age-related phenotypes. The study explores genetic correlations that may contribute to understanding the underlying factors of aging and longevity.

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