Inhibition of CD45-specific phosphatase activity restores the differentiation potential of aged mesenchymal stromal cells: implications in regenerative medicine.

Madhurima Das, Isha Behere, Ganesh Ingavle, Anuradha Vaidya, Vaijayanti Prakash Kale

Symbiosis Centre for Stem Cell Research, Symbiosis International (Deemed University), Pune, 412115, India.Symbiosis Centre for Stem Cell Research, Symbiosis International (Deemed University), Pune, 412115, India. · pubmed

Paper

Abstract

Aging affects the reparative potency of mesenchymal stem/stromal cells (MSCs) by diminishing their proliferation and differentiation capability; making them unsuitable for regenerative purposes. Earlier we showed that MSCs acquire the expression of CD45 as a consequence of aging, and this increased expression is associated with downregulated expression of osteogenic markers and upregulated expression of adipogenic and osteoclastogenic markers. However, whether CD45 is actively involved in the aging-mediated deregulated differentiation in the MSCs was not elucidated.

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Research summary

Inhibition of CD45-specific phosphatase activity can restore the differentiation potential of aged mesenchymal stromal cells. This research addresses a mechanism related to aging that affects stem cell functionality, which is crucial for regenerative medicine and longevity.

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