Development and aging of resident endothelial stem cells in pre-existing blood vessels.

Fitriana N Rahmawati, Nobuyuki Takakura

Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan. Electronic address: [email protected] of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan. Electronic address: [email protected]. · pubmed

Paper

Abstract

Organ-specific somatic stem cells play an important role in supporting tissue turnover and facilitating regeneration on injury. Hematopoietic stem cells are one of the most established organ-specific somatic cells that have been frequently used for transplantation therapy. Recently, there has been a growing interest in other organ-specific somatic cells, including vascular endothelial stem cells (VESCs). We have previously reported on the use of CD157 and CD200 as markers to isolate VESCs from adult mouse organs, particularly the liver. In this review, we aimed to summarize, based on our previous research, how CD157⁺CD200⁺ VESCs in the liver develop from the fetal stage to postnatal life, what transcriptional regulatory mechanisms govern them, and how VESCs change with aging.

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Research summary

The paper discusses the development and aging of vascular endothelial stem cells (VESCs) and their transcriptional regulatory mechanisms. This research is relevant as it explores the role of stem cells in aging and potential implications for tissue regeneration, which are critical aspects of longevity research.

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