Click Chemistry-Assisted Rejuvenation of Aging T Cells Sensitizes Aged Mice to Tumor Immunotherapy.

Xue-Feng Bai, Jun-Chi Ma, Cheng Zhang, Zhu Chen, Jinlian He, Si-Xue Cheng, Xian-Zheng Zhang

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. · pubmed

Paper

Abstract

Enormous resources have been devoted to address the suboptimal response of tumor patients to immunotherapy. However, a crucial yet often overlooked factor in these effects is the strong correlation between the occurrence and development of tumors and the immune dysfunction associated with aging. Our study aims to rejuvenate aging T cells within tumor-draining lymph nodes (TdLNs) by using targeted delivery of rapamycin, a macrolide capable of mitigating aging-related decline in immune function, thereby enhancing the antitumor efficacy of immunotherapy in aged mice. The targeted delivery system relies on a bioorthogonal reaction that harnesses the click chemistry between the azide (N

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Research summary

The paper claims that targeted delivery of rapamycin can rejuvenate aging T cells and enhance the efficacy of tumor immunotherapy in aged mice. This research addresses the immune dysfunction associated with aging, which is a root cause of age-related decline in immune function, making it relevant to longevity research.

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