Novel Insights to Mitochondrial Impact in Aging Skeletal Muscle.
Abstract
Our Perspective for Progress highlights sex differences in skeletal muscle mitochondrial function that evolve with aging, with an influence of denervation emerging in advanced age. Gaps include knowledge about mitochondrial alterations in microdomains of muscle fibers, plasticity of the mitochondrial reticulum to acute muscle contractions, and advanced age of both sexes.
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Research summary
The paper discusses sex differences in mitochondrial function in aging skeletal muscle and highlights gaps in understanding these alterations. This research is relevant as it addresses mitochondrial function, which is a key factor in the aging process and could contribute to understanding the root causes of aging and age-related decline in muscle function.
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