Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3/SOD2 pathway in osteoarthritis.

Huanyu Jiang, Yantao Zhang, Piyao Ji, Jianghua Ming, Yaming Li, Yan Zhou

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China. · pubmed

Paper

Abstract

Osteoarthritis (OA) is an age-related degenerative disease that affects bones and joints. The hallmark pathogenesis of OA is associated with chondrocyte senescence. Surfactant protein D (SP-D) is a member of the innate immune proteins family, which can inhibit the immune inflammatory response of chondrocytes. However, the effect of SP-D on chondrocyte senescence phenotype is poorly studied. The present study investigated the phenotypic regulation of OA chondrocyte senescence mediated by SP-D and explored the underlying molecular mechanism.

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Research summary

Surfactant protein D alleviates chondrocyte senescence by upregulating the SIRT3/SOD2 pathway in osteoarthritis. The study addresses a mechanism related to cellular senescence, which is a key aspect of aging and age-related diseases.

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