KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging.

Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M Gómez de Las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva M Blanco, Álvaro Fernández-Almeida, David Abia, María Josefa Rodríguez, Cristina M Fernández-Díaz, María Beatriz Álvarez-Flores, Ana Ramírez de Molina, Sascha Jung, Antonio Del Sol, Virginia Zorita, Fátima Sánchez-Cabo, Carlos Torroja, María Mittelbrunn

Departamento de Biología Molecular, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.Departamento de Biología Molecular, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain. · pubmed

Paper

Abstract

Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4

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Research summary

The paper claims that KLRG1 identifies a subset of regulatory T cells with mitochondrial alterations that increase with aging. This research is relevant as it explores the cellular mechanisms associated with aging, potentially addressing the root causes of age-related decline in immune function.

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