miR-484 in Hippocampal Astrocytes of Aged and Young Rats Targets CSF-1 to Regulate Neural Progenitor/Stem Cell Proliferation and Differentiation Into Neurons.

Jiahua Qu, Zhichao Lu, Yongbo Cheng, Song Deng, Wei Shi, Qianqian Liu, Yuejuan Ling

Research Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.Research Center of Clinical Medicine, Co-Innovation Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China. · pubmed

Paper

Abstract

Aging-related cognitive decline is closely linked to the reduced function of neural progenitor/stem cells (NPSCs), which can be influenced by the neural microenvironment, particularly astrocytes. The aim of this study was to explore how astrocytes affect NPSCs and cognitive function during aging.

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Research summary

The paper claims that miR-484 in hippocampal astrocytes regulates neural progenitor/stem cell proliferation and differentiation into neurons. This research addresses the mechanisms underlying cognitive decline in aging, which is directly related to the function of neural progenitor/stem cells and their potential role in longevity and age-related cognitive health.

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