Associations between five indicators of epigenetic age acceleration and all-cause and cause-specific mortality among US adults aged 50 years and older.

Yun Zou, Jing Huang, Xiaoli Tang, Jixiong Xu

Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, No 17 Yongwaizheng St., Nanchang, 330006, Jiangxi Province, People's Republic of China.Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, No 17 Yongwaizheng St., Nanchang, 330006, Jiangxi Province, People's Republic of China. · pubmed

Paper

Abstract

Although DNA methylation age estimators (DNAmAges) are reliable tools for predicting aging, their effectiveness in predicting mortality risk has not been fully validated. This study compared the predictive utility of five different DNAmAges (HorvathAge, HannumAge, PhenoAgeAge, GrimAge and GrimAge2) for all-cause and cause-specific mortality among adults aged ≥ 50 years.

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Research summary

This study evaluates the predictive utility of various DNA methylation age estimators for mortality risk in older adults. The paper is relevant as it investigates biomarkers of aging that could potentially inform interventions aimed at extending lifespan and improving health in aging populations.

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