Lipid droplets: Emerging therapeutic targets for age-related metabolic diseases.

Zheying Ma, Shou Pan, Yaming Yang, Huiqian Ren, Sikun Yin, Qianyu Chen, Zhenxian An, Xiaoqin Zhao, Zujie Xu

School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China.School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China. · pubmed

Paper

Abstract

Lipids metabolism is crucial in regulating aging and metabolic diseases. Lipid droplets (LDs) are dynamic, complex organelles responsible for the storage and release of neutral lipids, essential for maintaining lipid homeostasis and energy metabolism. Aging accelerates the accumulation of LDs, functional deterioration, and metabolic disorders, thereby inducing age-related metabolic diseases (ARMDs). This review examines published datasets on the association between LDs and ARMDs, focusing on the structure and function of LDs, their interactions with other organelles, and associated proteins. Furthermore, we explore the potential mechanisms by which LDs mediate the onset of ARMDs, including Alzheimer's disease (AD), sarcopenia, metabolic cardiomyopathy, non-alcoholic fatty liver disease (NAFLD), and cancer. Lastly, we discuss intervention strategies aimed at targeting LDs to improve outcomes in ARMDs, including exercise, dietary, and pharmacological interventions.

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Research summary

Lipid droplets play a significant role in the onset of age-related metabolic diseases. The paper is relevant as it explores the mechanisms by which lipid metabolism affects aging and proposes intervention strategies targeting lipid droplets to potentially mitigate age-related metabolic disorders.

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