Biological age acceleration and interaction with genetic predisposition in the risk of type 2 diabetes and coronary artery disease.

Guangrui Yang, Xihao Du, Xuanwei Jiang, Jingxuan Wang, Shuxiao Shi, Victor W Zhong

Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, 415 East No. 1 Building, 227 South Chongqing Rd, Shanghai, 200025, China. · pubmed

Paper

Abstract

Biological age (BA), compared to chronological age, offers a more accurate reflection of aging status. In this prospective UK Biobank study, BA acceleration was measured using the Klemera-Doubal method BA (KDM-BA) and Phenotypic age (PhenoAge). Cox models estimated associations of BA acceleration with incident T2D (n = 271,885) and CAD (n = 270,054). Both additive and multiplicative interactions between BA acceleration and polygenic risk score (PRS) were examined. Predictive performance was assessed by adding BA, PRS, and their interactions to traditional risk models. BA acceleration was positively associated with incident T2D (HR

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Research summary

Biological age acceleration is associated with an increased risk of type 2 diabetes and coronary artery disease. This paper is relevant as it explores biological age as a potential underlying factor in age-related diseases, contributing to the understanding of aging mechanisms.

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