Associations of cardiorespiratory fitness with brain white matter microstructural integrity and white matter hyperintensity volume across the adult lifespan.

Junyeon Won, Takashi Tarumi, Tsubasa Tomoto, Kevin Shan, Karen M Rodrigue, Kristen M Kennedy, Denise C Park, Rong Zhang

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA.Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX, 75231, USA. · pubmed

Paper

Abstract

Higher cardiorespiratory fitness (CRF) is associated with less deterioration in brain microstructural white matter (WM) integrity in older adults assessed with MRI diffusion tensor imaging (DTI) and brain WM hyperintensities (WMH) volume measured with fluid-attenuated-inversion-recovery (FLAIR) imaging. This study investigated associations of CRF measured with peak oxygen consumption (V̇O

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Research summary

Higher cardiorespiratory fitness is associated with better brain white matter integrity and reduced hyperintensity volume in older adults. This study is relevant as it explores the relationship between physical fitness and brain health, which can contribute to understanding mechanisms that influence aging and longevity.

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