Programmed wound healing in aged skin may be enhanced by mesenchymal cell loaded gene-activated scaffolds.

Priya Das, Martin Maresch, Nigamananda Dey, Noof Sulaiman, Amr Gamal Ashour, Hamad M Ammar, Mohammed Basem, Mohammed A Al Muharraqi, Matthew McGrath, Melvin Varghese Jacob, Fergal J O'Brien, Michael B Keogh

TERG Bahrain, School of Postgraduate Studies and Research, Royal College of Surgeons in Ireland, Manama, Kingdom of Bahrain.TERG Bahrain, School of Postgraduate Studies and Research, Royal College of Surgeons in Ireland, Manama, Kingdom of Bahrain. · pubmed

Paper

Abstract

Aging can prolong the wound healing and is associated with decline in stem cells, delays in cellular migration, and lower vascularization. Tissue engineering has largely evolved to incorporate advanced three-dimensional wound dressings, scaffolds, and hydrogels that may be seeded with mesenchymal stromal cells (MSCs) to foster an environment conducive to regeneration and enhance the healing process. The effectiveness of stem cell-seeded scaffolds can be improved by incorporating activating agents such as nucleic acids resulting in gene-activated scaffolds (GAS), thereby facilitating targeted wound healing in aged patients. In this study, we assess the

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Research summary

The paper claims that mesenchymal cell loaded gene-activated scaffolds can enhance wound healing in aged skin. This research is relevant as it addresses the mechanisms of wound healing in the context of aging, aiming to improve regenerative processes that decline with age.

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