Multi-omics Analysis Sheds Light on the Extracellular Role of PCMT1.

Jie Wang, Jia Xia, Juncheng Su, Ziyi Cao, Wen Yang, Peng Zhang, Yingjie Xu

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China. · pubmed

Paper

Abstract

Proteins are constantly damaged by intracellular and extracellular factors, particularly under stress conditions, leading to an accumulation of modified proteins such as isoaspartate (isoD), which is linked to aging and various diseases. The repair enzyme PCMT1 (protein-l-isoaspartate

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that PCMT1 plays a significant role in repairing damaged proteins linked to aging. The focus on a repair enzyme related to protein damage and its implications for aging processes makes it relevant to longevity research.

Author of this paper? Send a correction.