Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/MAPK.

Jiaqi Zhang, Wenxue Zheng, Zhengjie Zhou, YiMing An, Haoyu Zheng, Yanan Zhang, Yuchen Wei, Qianhua Zhang, Jingtong Zheng, Fang Wang

Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China. · pubmed

Paper

Abstract

Polygalae Radix has high pharmacological activity and has been widely used as a sedative and tranquilizer to increase cognitive function, prevent epilepsy, and treat respiratory diseases such as bronchitis. However, its role in delaying aging and decreasing oxidative stress and its main functional factors have not been thoroughly studied.

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Research summary

Aqueous Polygalae Radix extract prolongs lifespan in C. elegans and alleviates oxidative stress in mice. The study investigates the potential of a natural extract to influence aging processes and oxidative stress, which are central to longevity research.

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