Taurine ameliorates cellular senescence associated with an increased hydrogen sulfide and a decreased hepatokine, IGFBP-1, in CCl4-induced hepatotoxicity in mice.
Abstract
This study investigated the protective effects of taurine against cellular senescence and hepatokine secretion in a mouse model of carbon tetrachloride (CCl4)-induced chronic liver injury. Oral taurine administration by tap water containing 3 % taurine significantly attenuated liver damage, as evidenced by reduced serum AST, ALT level and hepatic lipid peroxidation. Importantly, hepatic taurine level is reduced in CCl4-induced injury model, while taurine administration recovered it. Moreover, taurine administration decreased the numbers of p21-positive senescent cells in liver tissue of CCl4-treated mice. Taurine increases hydrogen sulfide (H
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Research summary
Taurine administration reduces cellular senescence and liver damage in a mouse model of chronic liver injury. The study addresses cellular senescence, a key aspect of aging, and explores a potential intervention that may mitigate age-related liver dysfunction.
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