The Genomics of Aging at the Single-Cell Scale.

Wei Zhou, Junyue Cao

Laboratory of Single-Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA; email: [email protected] of Single-Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA; email: [email protected]. · pubmed

Paper

Abstract

Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated cellular changes that contribute to disrupted system homeostasis and increased vulnerability to age-related diseases. Despite the abundance of data generated over the past decade, a systematic understanding of how aging affects cell type-specific populations across the entire mammalian organism remains lacking-a critical gap for elucidating the cellular foundations of aging-related system dysfunction. In this review, we address this knowledge gap by summarizing recent single-cell studies examining the impact of aging on cell type-specific population changes across mammalian organs. We also review the impact of gender and anti-aging interventions on cell population dynamics in aged mammals. This work provides a comprehensive catalog of cellular states susceptible to aging, highlighting potential therapeutic targets for aging and age-related diseases.

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Research summary

The paper claims to summarize the impact of aging on cell type-specific population changes across mammalian organs. This work is relevant as it addresses the cellular foundations of aging and identifies potential therapeutic targets for age-related diseases, contributing to the understanding of aging mechanisms.

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