Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS-STING Pathway and Reverses Macrophage-Like VSMC Phenotypes in Progeroid DNA-Repair-Deficient Ercc1

S J M Stefens, J van der Linden, J M Heredia-Genestar, R M C Brandt, S Barnhoorn, I Nieuwenhuizen-Bakker, N van Vliet, J H M Odijk, Y Ridwan, D Stuijts, M Batenburg, J H J Hoeijmakers, R Kanaar, J Essers, I van der Pluijm

Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands. · pubmed

Paper

Abstract

Aging is a major risk factor for cardiovascular diseases, and the accumulation of DNA damage significantly contributes to the aging process. This study aimed to identify the underlying molecular mechanisms of vascular aging in DNA-repair-deficient progeroid Ercc1

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Research summary

Dietary restriction mitigates vascular aging by modulating the cGAS-STING pathway and reversing macrophage-like VSMC phenotypes in a progeroid model. This research addresses the molecular mechanisms underlying vascular aging, which is a critical aspect of the aging process and its associated diseases.

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