Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II).

Valentin Max Vetter, Kamil Demircan, Jan Homann, Thilo Samson Chillon, Michael Mülleder, Orr Shomroni, Elisabeth Steinhagen-Thiessen, Markus Ralser, Christina M Lill, Lars Bertram, Lutz Schomburg, Ilja Demuth

Department of Endocrinology and Metabolic Diseases (Including Division of Lipid Metabolism), Lipid Clinic at the Interdisciplinary Metabolism Center, Biology of Aging Working Group, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. [email protected] of Endocrinology and Metabolic Diseases (Including Division of Lipid Metabolism), Lipid Clinic at the Interdisciplinary Metabolism Center, Biology of Aging Working Group, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. [email protected]. · pubmed

Paper

Abstract

Biological age reflects inter-individual differences in biological function and capacity beyond chronological age. DNA methylation age (DNAmA) and its deviation from chronological age, DNAmA acceleration (DNAmAA), which was calculated as residuals of leukocyte cell count adjusted linear regression of DNAmA on chronological age, were used to estimate biological age in this study. Low levels of serum selenium, selenoprotein P (SELENOP), and the selenocysteine-containing glutathione peroxidase 3 (GPx3) are associated with adverse health outcomes and selenium supplementation is discussed as an anti-aging intervention.

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Research summary

Low blood levels of selenium, selenoprotein P, and GPx3 are associated with accelerated biological aging. The study investigates biomarkers linked to biological aging, suggesting a potential intervention (selenium supplementation) that could address underlying mechanisms of aging rather than merely treating age-related symptoms.

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