The influence of the geroprotective cytokine on the transcriptome of young and senescent mesenchymal stem cells.

Liya G Kondratyeva, Diana K Matveeva, Maria I Ezdakova, Marina V Utkina, Andrey Yu Ratushnyy

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Miklukho-Maklaya, 16/10, Moscow, 117997, Russia. [email protected]. · pubmed

Paper

Abstract

Increasing longevity and the growing elderly population necessitate a deeper understanding of aging mechanisms to prolong productive life and improve treatments for age-related diseases linked with cellular senescence. Mesenchymal stem cells (MSCs) are crucial for maintaining tissue homeostasis, but their physiological changes during senescence are not well understood. Growth differentiation factor 11 (GDF11) has emerged as a potential rejuvenation factor, enhancing MSC viability, mobility, and angiogenic functions, which improves outcomes in ischemic models and cardiac repair. This study aims to identify transcriptomic changes in young and senescent MSCs influenced by GDF11, highlighting its potential in MSC-based therapies.

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Research summary

The paper claims that GDF11 influences transcriptomic changes in young and senescent mesenchymal stem cells. This research is relevant as it explores a potential rejuvenation factor that could address the underlying mechanisms of aging and cellular senescence, contributing to longevity research.

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