Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation.

Wei Nong, Xiaoli Chen, Yixin Chen, Xueping Feng, Wen Kong, Rui Chi, Li Yan, Zhiquan Wei

Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi Traditional Chinese Medicine University, Nanning 530200, China. · pubmed

Paper

Abstract

Extracellular β-amyloid protein (Aβ) plaques are prominent pathological feature of Alzheimer's disease (AD). Aβ oligomers and plaques induce sustained microglial activation via the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/interferon regulatory factor 5 (IRF5) signaling pathway. This microglial activation-mediated neuroinflammation can accelerate neuronal cell senescence. Consequently, the regulation of the AMPK/mTOR/IRF5 pathway presents a potential therapeutic target for AD, as it may inhibit neuroinflammation and delay neuronal cell senescence. Mangiferin, a bioactive natural polyphenol extracted from the leaves of

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Research summary

The paper claims that mangiferin can delay neuronal cell senescence by inhibiting neuroinflammation through the AMPK/mTOR/IRF5 pathway. This research addresses the underlying mechanisms of neuroinflammation and cellular senescence, which are relevant to the aging process and potential interventions for age-related diseases like Alzheimer's.

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