At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle.

Toby L Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B Malik, Nicholas P Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M Dungan, Kevin A Murach

Exercise Science Research Center, Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, Arkansas, USA. · pubmed

Paper

Abstract

Senescent cells emerge with aging and injury. The contribution of senescent cells to DNA methylation age (DNAmAGE) in vivo is uncertain. Furthermore, stem cell therapy can mediate "rejuvenation", but how tissue regeneration controlled by resident stem cells affects whole tissue DNAmAGE is unclear. We assessed DNAmAGE with or without senolytics (BI01) in aged male mice (24-25 months) 35 days following muscle healing (BaCl

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Research summary

The paper claims that senolytic administration (BI01) affects DNA methylation age and the methylome in aged skeletal muscle. This research is relevant as it explores the role of senescent cells in aging and tissue regeneration, addressing potential interventions that could mitigate the effects of aging at a cellular level.

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